PeproTech重组小鼠PDGF-AA,货号:315-14
PeproTech重组小鼠PDGF-AA,货号:315-14
PeproTech重组小鼠PDGF-AA,货号:315-14
品牌: PeproTech
产地 :美国
货号: 315-17
保存条件: -20oC
供应商: 深圳9游总区生物科技有限公司
英文名: Recombinant Murine PDGF-AA
数量: 大量
保质期: 1年以上
Synonyms :
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Platelet-Derived Growth Factor-AA, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)
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Description :
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PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-AA is a 28.7 kDa disulfide-linked homodimer of two A chains (250 total amino acids).
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Catalog #:
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315-17
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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Biological Activity :
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Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED 50 for this effect is 8-10 ng/ml.
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AA Sequence :
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MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATSNLN PDHREEETGR RRESGKNRKR KRLKPT
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PubMed Link :
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Country of Origin :
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USA
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