PeproTech重组小鼠sCD40Ligand/TRAP,货号:315-15
PeproTech重组小鼠sCD40Ligand/TRAP,货号:315-15
PeproTech重组小鼠sCD40Ligand/TRAP,货号:315-15
品牌 :PeproTech
产地 :美国
货号: 315-15
规格:5µg/25µg/1mg
数量: 大量
供应商: 深圳9游总区生物科技有限公司
保存条件: -20℃
保质期: 1年以上
英文名: Recombinant Murine sCD40Ligand/TRAP
Synonyms :
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soluble CD40 Ligand, TNFSF5, TRAP, CD154, gp39, T-BAM
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Description :
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CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.
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Catalog #:
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315-15
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Biological Activity :
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Determined by its ability to induce TNF-alpha and MIP-1 alpha production by murine splenocytes. The expected ED 50 for this effect is < 0.1 µg/ml.
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Selected References :
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AA Sequence :
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MQRGDEDPQI AAHVVSEANS NAASVLQWAK KGYYTMKSNL VMLENGKQLT VKREGLYYVY TQVTFCSNRE PSSQRPFIVG LWLKPSSGSE RILLKAANTH SSSQLCEQQS VHLGGVFELQ AGASVFVNVT EASQVIHRVG FSSFGLLKL
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PubMed Link :
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Country of Origin :
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USA
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