PeproTech重组人BMP-2/120-02
PeproTech重组人BMP-2/120-02
PeproTech重组人BMP-2/120-02
产地: 美国
品牌: PeproTech
货号: 120-02
规格:2µg/10µg/1mg
保存条件: -20℃
英文名: Recombinant Human BMP-2
保质期: 1年以上
供应商:深圳9游总区生物科技有限公司
Synonyms :
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BMP-2A
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Description :
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BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
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Catalog #:
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120-02
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Biological Activity :
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Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED 50 for this effect is 0.5-1.0 μg/ml.
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Selected References :
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AA Sequence :
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MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
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PubMed Link :
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Country of Origin :
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USA
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Size A
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2µg
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Size B
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10µg
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5
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Size C
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1mg
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00
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Special Sizes:
Many products can be ordered in custom sizes. Please to contact with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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