Synonyms :

Resistin-like beta, Cysteine-rich secreted protein FIZZ2

Description :

Human RELM-β is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM-β and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELM-β is highly homologous to that of the adipose-derived cytokine Resistin and RELM-α. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X₁₁ -C-X₈ -C-X-C-X₃ -C-X₁₀ -C-X-C-X-C-X₉ -C-C. Recombinant Human RELM-β is a disulfide-linked homodimer with a total molecular weight of 19.0 kDa, consisting of two 89 amino acid residue chains.

Catalog #:

450-22

Source :

E.coli

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level :

Endotoxin level is less than 0.1 ng per µg (1EU/µg).

Biological Activity :

Not Available at this time.

Selected References :

AA Sequence :

MQCSLDSVMD KKIKDVLNSL EYSPSPISKK LSCASVKSQG RPSSCPAGMA VTGCACGYGC GSWDVQLETT CHCQCSVVDW TTARCCHLT

PubMed Link :

Country of Origin :

USA