/

全国统一客服热线:
0755-28715175

产品中心
Product
4产品中心
PeproTech重组人Sox2/110-03
PeproTech重组人Sox2/110-03
PeproTech重组人Sox2/110-03

PeproTech重组人Sox2/110-03

 详情说明

PeproTech重组人Sox2/110-03

品牌: PeproTech
产地: 美国

货号: 110-03

规格:5µg/25µg/1mg
供应商: 深圳9游总区生物科技有限公司
保存条件: -20℃
英文名: Recombinant Human Sox2
保质期: 1年以上

Synonyms :

none

Description :

Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in the capacity to form teratomas in immune-deficient mice. Recombinant human Sox2 is a 34.3 kDa protein containing 317 amino-acid residues.

Catalog #:

110-03

Source :

E.coli

Purity :

Greater than 95% by SDS-PAGE gel and HPLC analyses

Endotoxin Level :

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Biological Activity :

Data Not Available.

AA Sequence :

MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHM

PubMed Link :

Country of Origin :

USA

 

 

 

Size A 5µg  
 
Size B 25µg
 
Size C 1mg 00 
 

 


 

Special Sizes: 
Many products can be ordered in custom sizes. Please  to contact with your request.

 

Usage: 
For Research Use Only. Not for use in diagnostic or therapeutic procedures.



Copyright © 深圳9游总区生物科技有限公司版权所有

扫一扫,加关注

客户服务热线:
0755-33164177
13924667705
18665335907
0755-28715175


线