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PeproTech重组人TGF-beta2-Insect/100-35
PeproTech重组人TGF-beta2-Insect/100-35
PeproTech重组人TGF-beta2-Insect/100-35

PeproTech重组人TGF-beta2-Insect/100-35

 详情说明

PeproTech重组人TGF-beta2-Insect/100-35

品牌 :PeproTech
产地: 美国

货号: 100-35

规格:1µg/5µg/1mg
保质期: 1年以上
供应商: 深圳9游总区生物科技有限公司
英文名: Recombinant Human TGF-beta2-Insect
保存条件: -20℃

Synonyms :

Transforming Growth Factor-beta2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin

Description :

The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.* Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Catalog #:

100-35

Source :

(BTI-Tn-5B1-4) High-5 Insect Cells*

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses

Endotoxin Level :

Endotoxin level is less than 0.1 ng per µg (1EU/µg).

Biological Activity :

Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED 50 was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Selected References :

AA Sequence :

ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS

PubMed Link :

Country of Origin :

USA

 

 

 

Size A 1µg    
 
Size B 5µg  
 
Size C 1mg 00   
 

 


 

Special Sizes: 
Many products can be ordered in custom sizes. Please  to contact with your request.

 

Usage: 
For Research Use Only. Not for use in diagnostic or therapeutic procedures.


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