PeproTech重组人Heregulin beta-1/100-03
PeproTPeproTech重组人Heregulin beta-1/100-03
PeproTech重组人Heregulin beta-1/100-03
品牌: PeproTech
产地 :美国
货号: 100-03
保质期:1年以上
规格:10µg/50µg/1mg
英文名: Recombinant Human Heregulin beta-1
供应商: 深圳9游总区生物科技有限公司
保存条件: -20℃
Synonyms :
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Neuregulin1 (NRG1-β</>1), Neu differentiation factor (rat)
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Description :
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Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β</>1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-β</>1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-β</>1 (HRG1-β</>1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-β</>1 (65 amino acid residues).
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Catalog #:
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100-03
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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Biological Activity :
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The ED 50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
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Selected References :
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AA Sequence :
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SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
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PubMed Link :
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Country of Origin :
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USA
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Size A
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10µg
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Size B
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50µg
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Size C
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1mg
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Special Sizes:
Many products can be ordered in custom sizes. Please to contact with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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